PART IClinical Evaluation1 General Aspects of the Patient’s Neurologic History2 Neurologic Examination of the Older Child3 Neurologic Examination after the Newborn Period Until 2 Years of Age4 Neurologic Examination of the Term and Preterm Infant5 Muscular Tone and Gait Disturbances6 Vision Loss7 Hearing Impairment8 Vertigo9 Taste and Smell10 Neuropsychological Assessment
PART IINeurodiagnostic Testing11 Spinal Fluid Examination12 Pediatric Neuroimaging13 Pediatric Neurophysiologic Evaluation
PART IIIEmerging Neuroscience Concepts14 Microstructural and Functional Connectivity in the Developing Brain15 Stem Cell Transplantation for Childhood Neurologic Disorders16 Cellular and Animal Models of Neurologic Disease
PART IVPerinatal Acquired and Congenital Neurologic Disorders17 Neonatal Neurointensive Care18 Neonatal Seizures19 Hypoxic-Ischemic Brain Injury in the Term Newborn20 Cerebrovascular Disorders in the Newborn21 Neonatal Nervous System Trauma22 Injury to the Developing Preterm Brain: Intraventricular Hemorrhage and White Matter InjuryVideo 22.1 Endoscopic View of Clot at the Foramen of MonroVideo 22.2 Endoscopic Third Ventriculostomy in an Infant with Posthemorrhagic Hydrocephalus23 Perinatal Metabolic Encephalopathies
PART VCongenital Structural Defects24 Overview of Human BrainMalformations25 Disorders of Neural Tube Development26 Disorders of Forebrain Development27 Disorders of Cerebellar and Brainstem Development28 Disorders of Brain Size29 Malformations of Cortical Development30 Hydrocephalus and Arachnoid Cysts31 Congenital Anomalies of the Skull32 Developmental Encephalopathies33 Prenatal Diagnosis of Structural Brain Anomalies
PART VIGenetic, Metabolic and Neurocutaneous Disorders34 Neurogenetics in the Genome Era35 Chromosomes and Chromosomal Abnormalities36 Approach to the Patient with a Metabolic Disorder37 Aminoacidemias and Organic Acidemias38 Inborn Errors of Urea Synthesis39 Diseases Associated with Primary Abnormalities in Carbohydrate Metabolism40 Disorders of Glycosylation41 Lysosomal Storage Diseases42 Mitochondrial Diseases43 Peroxisomal Disorders44 Neurotransmitter-Related Disorders45 Phakomatoses and Allied Conditions46 Disorders of Vitamin Metabolism47 Nutrition and the Developing Brain48 The Neuronal Ceroid Lipofuscinosis Disorders49 Channelopathies
PART VIINeurodevelopmental Disorders50 Neurodevelopmental Disabilities: Conceptual Framework51 Global Developmental Delay and Intellectual Disability52 Cognitive and Motor Regression53 Developmental Language Disorders54 Nonverbal Learning Disabilities and Associated Disorders55 Dyslexia56 Attention Deficit–Hyperactivity Disorder57 Autistic Spectrum Disorders58 Management of Common Comorbidities Associated with Neurodevelopmental Disorders59 Treatment of Neurodevelopmental Disorders60 Neuropsychopharmacology
PART VIIIEpilepsy61 Overview of Seizures and Epilepsy in Children62 Principles of Management and Outcome63 Neurophysiology of Seizures and Epilepsy64 Epilepsy Genetics65 Febrile Seizures66 Generalized Seizures67 Focal and Multifocal Seizures68 Epileptic Spasms and Myoclonic Seizures69 Status Epilepticus70 Electroclinical Syndromes: Neonatal Onset71 Electroclinical Syndromes: Infantile Onset72 Electroclinical Syndromes: Childhood Onset73 Electroclinical Syndromes: Adolescent OnsetVideo 73.1 Focal Seizure with Dyscognitive Features74 Focal Structural Epilepsy75 Other Acquired Epilepsies: Trauma, Stroke, Tumors76 Inherited Metabolic Epilepsies77 Antiseizure Drug Therapy in Children78 Epilepsy Surgery in the Pediatric Population79 Neuromodulation in Epilepsy80 Ketogenic Diets81 Pediatric Psychogenic Nonepileptic Seizures and Psychiatric Disorders82 Behavioral, Cognitive, and Social Aspects of Childhood Epilepsy83 Mortality in Children with Epilepsy
PART IXNonepileptiform Paroxysmal Disorders and Disorders of Sleep84 Headache in Children and Adolescents85 Breath-Holding Spells and Reflex Anoxic Seizures86 Syncope and Postural Orthostatic Tachycardia Syndrome87 Nocturnal Paroxysmal Disorders88 Disorders of Excessive Sleepiness89 Restless Legs Syndrome and Periodic Limb Movement Disorder in Children and Adolescents90 Apparent Life-Threatening Event and Sudden Infant Death SyndromePART XDisorders of Balance and Movement91 The Cerebellum and the Hereditary Ataxias92 Acute Cerebellar AtaxiaVideo 92.1 Signs of Ataxia93 Movement Disorders: An Overview94 Paroxysmal Dyskinesias95 Movement Disorders of Infancy96 Drug-Induced Movement Disorders in Children97 Cerebral Palsy98 Tics and Tourette Syndrome
PART XIWhite Matter Disorders99 Genetic and Metabolic Disorders of the White Matter100 Acquired Disorders Affecting the White Matter
PART XIIBrain Injury and Disorders of Consciousness101 Disorders of Consciousness in Children102 Traumatic Brain Injury in Children103 Abusive Head Trauma104 Hypoxic-Ischemic Encephalopathy in Infants and Older Children105 Disorders of Intracranial Pressure106 Spinal Cord Injury107 Determination of Brain Death in Infants and Children
PART XIIICerebrovascular Disease in Children108 Development and Function of the Cerebrovascular System109 Arterial Ischemic Stroke in Infants and Children110 Sinovenous Thrombosis in Infants and Children111 Vascular Malformations, Intracerebral Hemorrhage, and Subarachnoid Hemorrhage in Infants and Children112 Cerebral Arteriopathies in Children113 Coagulation Disorders and Cerebrovascular Disease in Children
PART XIVInfections of the Nervous System114 Bacterial Infections of the Nervous System115 Viral Infections of the Nervous System116 Fungal, Rickettsial, and Parasitic Diseases of the Nervous System117 Neurologic Complications of Immunization
PART XVImmune Mediated Disorders of the Nervous System118 Paraneoplastic Neurologic Syndromes119 Immune-Mediated Epilepsy, Movement Disorders, and Hashimoto’s Encephalopathy in Children120 Opsoclonus Myoclonus SyndromeVideo 120.1 OMS Evaluation Scale121 Neurologic Manifestations of Rheumatic Disorders of Childhood
PART XVIPediatric Neurooncology122 Pediatric Neuro-oncology: An Overview123 Medulloblastoma124 Other Embryonal and Pineal Malignancies of the Central Nervous System125 Ependymoma126 Pediatric Brain Tumors – High-Grade Glioma127 Pediatric Low-Grade Glioma128 Diffuse Intrinsic Pontine Glioma129 Atypical Teratoid/Rhabdoid Tumors130 Central Nervous System Germinoma and Other Germ Cell Tumors131 Craniopharyngioma, Meningiomas, and Schwannomas132 Pediatric Intradural Spinal Cord Tumors133 System Cancer and the Central Nervous System Involvement134 Posttreatment Neurologic Sequelae of Pediatric Central Nervous System Tumors
PART XVIINeuromuscular Disorders135 Muscle and Nerve Development in Health and Disease136 Laboratory Assessment of the Child with Suspected Neuromuscular Disorders137 Clinical Assessment of Pediatric Neuromuscular Disorders138 The Floppy Infant139 Genetic Disorders Affecting the Motor Neuron: Spinal Muscular Atrophy140 Other Motor Neuron Diseases of Childhood141 Genetic Peripheral Neuropathies142 Acquired Peripheral Neuropathies143 Inflammatory Neuropathies144 Congenital Myasthenic Syndromes145 Acquired Disorders of the Neuromuscular Junction146 Duchenne and Becker Muscular Dystrophies147 Congenital, Limb Girdle and Other Muscular Dystrophies148 Congenital Myopathies149 Metabolic Myopathies150 Inflammatory Myopathies151 Channelopathies: Myotonic Disorders and Periodic Paralysis152 Management of Children with Neuromuscular Disorders
PART XVIIISystemic and Autonomic Nervous153 Endocrine Disorders of the Hypothalamus and Pituitary in Childhood and Adolescence154 Disorders of the Autonomic Nervous System: Autonomic Dysfunction in Pediatric Practice155 Disorders of Micturition and Defecation156 Poisoning and Drug-Induced Neurologic Diseases157 Neurologic Disorders in Children with Heart Disease158 Neurologic Disorders Associated with Renal Diseases159 Neurologic Disorders Associated with Gastrointestinal Diseases
PART XIXCare of the Child with Neurologic Disorders160 Counseling Children with Neurologic Disorders and Their Families161 Approaches to Personalized Medicine in Pediatric Neurology162 Pediatric Neurorehabilitation Medicine163 Pain Management and Palliative Care164 Ethical Issues in Child Neurology165 Transitional Care for Children with Neurologic Disorders166 Practice Guidelines in Pediatric Neurology167 Special Education Law as it Relates to Children with Neurologic Disorders168 Measurement of Health Outcomes in Pediatric Neurologic Disorders169 The Influence of Computer Resources on Child Neurology170 Education and Training of Child Neurologists and Workforce IssuesAPPENDIX AAPPENDIX BIndex